Immunochemistry

Anti-Cyclic Citrullinated Peptide (Anti-CCP)

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Citrulline is a non-standard amino acid, as it is not incorporated into proteins synthesis. Cyclic citrullinated peptide were equally specific for RA, but with a higher sensitivity with linear peptides. Detection of anti-CCP antibodies is used as an aid in the diagnosis of Rheumatoid Arthritis (RA).

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